MHC class I modulates NMDA receptor function and AMPA receptor trafficking

MHC class I modulates NMDA receptor function and AMPA receptor trafficking.

Proteins of the major histocompatibility complex class I (MHCI) are known for their role in immunity and have recently been implicated in long-term plasticity of excitatory synaptic transmission. However, the mechanisms by which MHCI influences synaptic plasticity remain unknown. Here we show that endogenous MHCI regulates synaptic responses mediated by NMDA-type glutamate receptors (NMDARs) in...

Memory retrieval requires ongoing protein synthesis and NMDA receptor activity-mediated AMPA receptor trafficking.

Whereas consolidation and reconsolidation are considered dynamic processes requiring protein synthesis, memory retrieval has long been considered a passive readout of previously established plasticity. However, previous findings suggest that memory retrieval may be more dynamic than previously thought. This study therefore aimed at investigating the molecular mechanisms underlying memory retrie...

The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function

Posttranslational regulation of AMPA receptor trafficking and function.

In the mammalian central nervous system, the majority of fast excitatory synaptic transmission is mediated by glutamate acting on AMPA-type ionotropic glutamate receptors. The abundance of AMPA receptors at the synapse can be modulated through receptor trafficking, which dynamically regulates many fundamental brain functions, including learning and memory. Reversible posttranslational modificat...

Analysis of Ampa Receptor Trafficking Ampa Receptor Trafficking: a Mechanism of Excitatory Synaptic Plasticity

Glutamate is the main excitatory neurotransmitter in the cortex and the tetrameric AMPA receptors (AMPARs) mediate the fast excitatory component of postsynaptic potential. Trafficking of AMPARs has been implicated in synaptic plasticity regulation, including long-term potentiation, long-term depression, and synaptic scaling. Two proteins, GRIP for stabilization at the synapse and PICK for inter...